Author: Iessi, Elisabetta; Cittadini, Camilla; Anticoli, Simona; Fecchi, Katia; Matarrese, Paola; Ruggieri, Anna
Title: Sex differences in antiviral immunity in SARSâ€CoVâ€2 infection: Mitochondria and mitomiR come into view Cord-id: laug5652 Document date: 2020_11_5
ID: laug5652
Snippet: Mitochondria are multifaceted organelles representing the "powerhouse of cells" for their function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in the regulation of innate and adaptive immune responses, including host defenses against viruses, as well as in inflammatory responses 1 . This peculiar role of mitochondria is principally due to the activation of adaptor mitochondrial proteins, known as mitochondrial antiviral signaling (MAVS) proteins. MAVS sense v
Document: Mitochondria are multifaceted organelles representing the "powerhouse of cells" for their function as bioenergetics and biosynthetic hubs. In addition, they play an essential role in the regulation of innate and adaptive immune responses, including host defenses against viruses, as well as in inflammatory responses 1 . This peculiar role of mitochondria is principally due to the activation of adaptor mitochondrial proteins, known as mitochondrial antiviral signaling (MAVS) proteins. MAVS sense viral RNA and trigger the activation of the transcription factor NF-kB or IFN pathways and autophagy, in order to clear the infection and avoid excessive inflammation, respectively1 .
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