Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_9
Snippet: During exacerbation, peak concentrations of MUC5AC (i.e. maximal concentrations detected during exacerbation) protein were increased compared to baseline with no significant increase observed for MUC5B (Fig.1c) . Frequent exacerbators (patients with a history of >2 exacerbations in the preceding year) had increased sputum MUC5AC concentrations at exacerbation presentation and at 2 weeks during exacerbation compared with infrequent exacerbators (0.....
Document: During exacerbation, peak concentrations of MUC5AC (i.e. maximal concentrations detected during exacerbation) protein were increased compared to baseline with no significant increase observed for MUC5B (Fig.1c) . Frequent exacerbators (patients with a history of >2 exacerbations in the preceding year) had increased sputum MUC5AC concentrations at exacerbation presentation and at 2 weeks during exacerbation compared with infrequent exacerbators (0 or 1 exacerbations in the preceding year), with no significant differences observed for MUC5B (Fig. 1d) .
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