Author: Tai, Chen-Jei; Li, Chia-Lin; Tai, Cheng-Jeng; Wang, Chien-Kai; Lin, Liang-Tzung
Title: Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds. Cord-id: l4qrqf1y Document date: 2015_1_1
ID: l4qrqf1y
Snippet: Cell-based systems are useful for discovering antiviral agents. Dissecting the viral life cycle, particularly the early entry stages, allows a mechanistic approach to identify and evaluate antiviral agents that target specific steps of the viral entry. In this report, the methods of examining viral inactivation, viral attachment, and viral entry/fusion as antiviral assays for such purposes are described, using hepatitis C virus as a model. These assays should be useful for discovering novel anta
Document: Cell-based systems are useful for discovering antiviral agents. Dissecting the viral life cycle, particularly the early entry stages, allows a mechanistic approach to identify and evaluate antiviral agents that target specific steps of the viral entry. In this report, the methods of examining viral inactivation, viral attachment, and viral entry/fusion as antiviral assays for such purposes are described, using hepatitis C virus as a model. These assays should be useful for discovering novel antagonists/inhibitors to early viral entry and help expand the scope of candidate antiviral agents for further drug development.
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