Author: Ali Punjani; Haowei Zhang; David J. Fleet
Title: Non-uniform refinement: Adaptive regularization improves single particle cryo-EM reconstruction Document date: 2019_12_16
ID: bqwmx5dy_62
Snippet: In this work, non-uniform refinement is contrasted with uniform refinement in which global FSCbased resolution estimates are used for filtering during iterative refinement. The fact that non-uniform refinement locally regularizes 3D maps during refinement indicates that there may in fact be significant structure resolved beyond the global FSC-based resolution to which final maps are filtered before visualization. We do not address this possibilit.....
Document: In this work, non-uniform refinement is contrasted with uniform refinement in which global FSCbased resolution estimates are used for filtering during iterative refinement. The fact that non-uniform refinement locally regularizes 3D maps during refinement indicates that there may in fact be significant structure resolved beyond the global FSC-based resolution to which final maps are filtered before visualization. We do not address this possibility here, but it does raise the interesting question of how one can then effectively measure resolution in general (similar to the premise of [2] ).
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