Microbial and autoantibody immunogenic repertoires in TIF1? autoantibody positive dermatomyositis

Spyridon Megremis; Thomas Walker; Xiaotong He; James O'Sullivan; William E.R. Ollier; Hector Chinoy; Neil Pendleton; Antony Payton; Lynne Hampson; Ian Hampson; Janine Lamb

Interestingly, there are case studies which report development of DM after vaccination against some of these viruses, notably HBV, HPV, influenza and VACV (Ignasi Rodriguez-Pinto, 2015) . Overall, the DM-specific viral signature includes viruses which can either directly infect muscle tissue and/or . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.007534 doi: bioRxiv preprint indirectly sabotage immune homeostasis. The observation that the respiratory and gastrointestinal systems are the primary physiological targets of these viruses agrees with previous observations regarding the high frequency of this type of infection in patients with juvenile-and adult-onset DM (Pachman et al., 2005; Svensson et al., 2017) . Moreover, the age-range of juvenile and adult onset DM coincides with the epidemiological peaks of respiratory infections during life (Kuan et al., 2019) .