Author: Rosanna Asselta; Elvezia Maria Paraboschi; Alberto Mantovani; Stefano Duga
Title: ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy Document date: 2020_4_2
ID: hrottr01_30
Snippet: Interestingly, this haplotype has been functionally linked to another eQTL (rs8134378), located at a known androgen-responsive enhancer for TMPRSS2, 13 kb upstream of the TMPRSS2 transcription start site 28 ( Figure 1B) . Hence, this haplotype is expected to up regulate TMPRSS2 gene expression in an androgen-specific way......
Document: Interestingly, this haplotype has been functionally linked to another eQTL (rs8134378), located at a known androgen-responsive enhancer for TMPRSS2, 13 kb upstream of the TMPRSS2 transcription start site 28 ( Figure 1B) . Hence, this haplotype is expected to up regulate TMPRSS2 gene expression in an androgen-specific way.
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