Selected article for: "mutation rate and replicative speed"
Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus
  • Document date: 2018_4_27
    • ID: 8p24gszj_31
    Snippet: The genetic interactions are quite strong as the two compensatory mutations exhibited 255 reciprocal sign epistasis. The speed-fidelity trade-off in the poliovirus RdRp appears to be a 256 generalizable phenomenon, as compensatory mutations that increased the replicative speed of 257 the 3D K359H antimutator also increased its mutation rate (Table S4) . Given the structural 258 similarity among viral RdRp, the polymerases of other RNA viruses are.....
    Document: The genetic interactions are quite strong as the two compensatory mutations exhibited 255 reciprocal sign epistasis. The speed-fidelity trade-off in the poliovirus RdRp appears to be a 256 generalizable phenomenon, as compensatory mutations that increased the replicative speed of 257 the 3D K359H antimutator also increased its mutation rate (Table S4) . Given the structural 258 similarity among viral RdRp, the polymerases of other RNA viruses are likely to be subject to the 11 same speed-fidelity trade-off, and we predict that the molecular mechanisms governing 260 polymerase kinetics and mutation rate will be similar.

    Search related documents:
    Co phrase search for related documents
    • genetic interaction and molecular mechanism: 1
    • genetic interaction and RNA virus: 1
    • molecular mechanism and mutation kinetic: 1
    • molecular mechanism and mutation rate: 1, 2
    • molecular mechanism and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • molecular mechanism and RNA virus polymerase: 1, 2
    • mutation rate and replicative speed: 1, 2, 3, 4, 5
    • mutation rate and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • mutation rate and speed fidelity: 1, 2, 3
    • mutation rate and speed fidelity trade: 1
    • replicative speed and speed fidelity: 1, 2
    • replicative speed and speed fidelity trade: 1