Author: Bastard, P.; Orlova, E.; Sozaeva, L.; Levy, R.; James, A.; Schmitt, M. M.; Ochoa, S.; Kareva, M.; Rodina, Y.; Gervais, A.; Voyer, T. le Rosain J.; Philippot, Q.; Neehus, A. L.; Shaw, E.; Migaud, M.; Bizien, L.; Ekwall, O.; Berg, S.; Beccuti, G.; Ghizzoni, L.; Thiriez, G.; Pavot, A.; Goujard, C.; Fremond, M. L.; Carter, E.; Rothenbuhler, A.; Linglart, A.; Mignot, B.; Comte, A.; Cheikh, N.; Hermine, O.; Breivik, L.; Husebye, E. S.; Humbert, S.; Rohrlich, P.; Coaquette, A.; Vuoto, F.; Faure, K.; Mahlaoui, N.; Kotnik, P.; Battelino, T.; Podkrajsek, K. T.; Kisand, K.; Ferre, E. M. N.; Dimaggio, T.; Rosen, L. B.; Burbelo, P. D.; McIntyre, M.; Kann, N. Y.; Shcherbina, A.; Pavlova, M.; Kolodkina, A.; Holland, S. M.; Zhang, ShenYing Crow Y. J.; Notarangelo, L. D.; Su, H. C.; Abel, L.; Anderson, M. S.; Jouanguy, E.; Neven, B.; Puel, A.; Casanova, J. L.; Lionakis, M. S.; Bastard, Paul; Orlova, Elizaveta; Sozaeva, Leila; Lévy, Romain; James, Alyssa; Schmitt, Monica M; Ochoa, Sebastian; Kareva, Maria; Rodina, Yulia; Gervais, Adrian; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Neehus, Anna-Lena; Shaw, Elana; Migaud, Mélanie; Bizien, Lucy; Ekwall, Olov; Berg, Stefan; Beccuti, Guglielmo; Ghizzoni, Lucia; Thiriez, Gérard; Pavot, Arthur; Goujard, Cécile; Frémond, Marie-Louise; Carter, Edwin; Rothenbuhler, Anya; Linglart, Agnès; Mignot, Brigite; Comte, Aurélie; Cheikh, Nathalie; Hermine, Olivier; Breivik, Lars; Husebye, Eystein S; Humbert, Sébastien; Rohrlich, Pierre; Coaquette, Alain; Vuoto, Fanny; Faure, Karine; Mahlaoui, Nizar; Kotnik, Primoz; Battelino, Tadej; Trebusak Podkrajsek, Katarina; Kisand, Kai; Ferré, Elise M N; DiMaggio, Thomas; Rosen, Lindsey B; Burbelo, Peter D; McIntyre, Martin; Kann, Nelli Y
Title: Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1 Cord-id: jqoqltba Document date: 2021_1_1
ID: jqoqltba
Snippet: Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with
Document: Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-a subtypes and/or IFN-;one had anti-IFN-beta and another anti-IFN-T, but none had anti-IFN-. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date