Author: Jingyue Ju; Xiaoxu Li; Shiv Kumar; Steffen Jockusch; Minchen Chien; Chuanjuan Tao; Irina Morozova; Sergey Kalachikov; Robert N. Kirchdoerfer; James J. Russo
Title: Nucleotide Analogues as Inhibitors of SARS-CoV Polymerase Document date: 2020_3_14
ID: hj675z1b_10
Snippet: The RdRp of SARS-CoV, referred to as nsp12, and its two protein cofactors, nsp7 and nsp8, shown to be required for the processive polymerase activity of nsp12, were cloned and purified as described. 41, 42 These three viral gene products have high homology (e.g., 96% identity and 98% similarity for nsp12, with similar homology levels at the amino acid level for nsp7 and nsp8) to the equivalent gene products from SARS-CoV-2, the causative agent of.....
Document: The RdRp of SARS-CoV, referred to as nsp12, and its two protein cofactors, nsp7 and nsp8, shown to be required for the processive polymerase activity of nsp12, were cloned and purified as described. 41, 42 These three viral gene products have high homology (e.g., 96% identity and 98% similarity for nsp12, with similar homology levels at the amino acid level for nsp7 and nsp8) to the equivalent gene products from SARS-CoV-2, the causative agent of COVID-19. A detailed description of the homologies of nsp7, nsp8 and nsp12 is included in Extended Data Fig. 1 which highlights key functional motifs in nsp12 described by Kirchdoerfer and Ward. 42 Of these, Motifs A, B, E, F and G are identical in SARS-CoV and SARS-CoV-2 at the amino acid level, and Motifs C and D display only conservative substitutions.
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