Microbial and autoantibody immunogenic repertoires in TIF1? autoantibody positive dermatomyositis

Spyridon Megremis; Thomas Walker; Xiaotong He; James O'Sullivan; William E.R. Ollier; Hector Chinoy; Neil Pendleton; Antony Payton; Lynne Hampson; Ian Hampson; Janine Lamb

The GO processes that were successfully represented in the DM-enriched autoantibody proteome are depicted as hubs (square nodes). Each hub is directly connected, through an edge, with the protein that is part of the specific GO process (circular nodes). Square node size is analogous to the number of interactions (edges). Nodes highlighted with red were exclusively identified in DM P20 (80% of nodes The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.007534 doi: bioRxiv preprint epitopes identified in DM. The Human immunodeficiency virus 1, Synechococcus phage syn9 and TRIM47 share a common epitope (branch length=0.000). Branch lengths represent phylogenetic distance (Kimura protein distance). . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.007534 doi: bioRxiv preprint