Author: Meytal Galilee; Akram Alian
Title: Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms Document date: 2018_4_16
ID: 4fuxbte0_4
Snippet: Based on the structure of Fab specific to IN CCD/NTD platform (9), we develop a peptide that, similar to Fab, inhibits IN multimerization and strand-transfer activity. Surprisingly, crystal structure and affinity experiments show that the peptide interferes with the CCD/CTD interfaces of IN. This structure, which features an overlooked SH3-docking platform crucial for IN multimerization, can now provide a template for the screening and developmen.....
Document: Based on the structure of Fab specific to IN CCD/NTD platform (9), we develop a peptide that, similar to Fab, inhibits IN multimerization and strand-transfer activity. Surprisingly, crystal structure and affinity experiments show that the peptide interferes with the CCD/CTD interfaces of IN. This structure, which features an overlooked SH3-docking platform crucial for IN multimerization, can now provide a template for the screening and development of novel anti-IN allosteric inhibitors.
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