Author: Le, Thi Khanh; Paris, Clément; Khan, Khadija Shahed; Robson, Fran; Ng, Wai-Lung; Rocchi, Palma
Title: Nucleic acid-based technologies targeting coronaviruses Cord-id: l9rmmllx Document date: 2020_11_27
ID: l9rmmllx
Snippet: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-C
Document: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), RNA-targeting CRISPR-Cas systems and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.
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