Selected article for: "density map and high resolution"
Author: Ali Punjani; Haowei Zhang; David J. Fleet
Title: Non-uniform refinement: Adaptive regularization improves single particle cryo-EM reconstruction
  • Document date: 2019_12_16
    • ID: bqwmx5dy_40
    Snippet: The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a small asymmetric 48kDa membrane protein with no soluble region [15] . Mutations in PfCRT are associated with the emergence of resistance to chloroquine and piperaquine as antimalarial treatments. The PfCRT dataset used here comprises 16,905 particle images of PfCRT in lipid nanodisc with a Fab bound, imaged with a 0.5175Ã… pixel size. It is available publicly as EMPIAR-1033.....
    Document: The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a small asymmetric 48kDa membrane protein with no soluble region [15] . Mutations in PfCRT are associated with the emergence of resistance to chloroquine and piperaquine as antimalarial treatments. The PfCRT dataset used here comprises 16,905 particle images of PfCRT in lipid nanodisc with a Fab bound, imaged with a 0.5175Ã… pixel size. It is available publicly as EMPIAR-10330 [15] . An early version of the non-uniform refinement algorithm was essential for reconstructing the published high resolution density map, into which a molecular model was built and from which biological insights were drawn [15] .

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