Determinants of vitamin D activation in patients with acute coronary syndromes and its correlation with inflammatory markers

Saghir Afifeh, Arraa Maddalena; Verdoia, Monica; Nardin, Matteo; Negro, Federica; Viglione, Filippo; Rolla, Roberta; De Luca, Giuseppe

Background Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide. Calcitriol (1,25(OH)2D) represents the perpetrator of the several systemic effects of vitamin D, including the anti-inflammatory, antithrombotic and anti-atherosclerotic action potentially preventing acute cardiovascular ischemic events. Variability in the transformation of vitamin D into 1,25(OH)2D has been suggested to modulate its cardioprotective benefits, however, the determinants of the levels of calcitriol and their impact on the cardiovascular risk have been seldom addressed and were therefore the aim of the present study. Methods A consecutive cohort of patients undergoing coronary angiography for acute coronary syndrome(ACS) were included. The levels of 25 and 1,25(OH)2 D were assessed at admission by chemiluminescence immunoassay kit LIAISON® Vitamin D assay (Diasorin Inc) and LIAISON® XL. Hypovitaminosis D was defined as 25(OH)D < 10 ng/ml, whereas Calcitriol deficiency as 1,25(OH)2D < 19.9 pg/ml. Results We included in our study 228 patients, divided according to median values of 1,25(OH)2D (