Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_12
Snippet: To this end, we acquired the publicly available expression datasets for TMPRSS2 and AR in non-cancerous lung and associated respiratory tissues from the Genomic Expression Omnibus (GEO). Across all tissue-type comparisons, we found no evidence for elevated TMPRSS2 or AR mRNA expression ( Fig.1 ) in males compared with females. Together, these results suggest that worse clinical manifestations of men with COVID-19 are unlikely to be associated wit.....
Document: To this end, we acquired the publicly available expression datasets for TMPRSS2 and AR in non-cancerous lung and associated respiratory tissues from the Genomic Expression Omnibus (GEO). Across all tissue-type comparisons, we found no evidence for elevated TMPRSS2 or AR mRNA expression ( Fig.1 ) in males compared with females. Together, these results suggest that worse clinical manifestations of men with COVID-19 are unlikely to be associated with TMPRSS2. However, this conclusion is limited to transcriptional information, and further studies are required to rule out the possibility of protein level differences in the human respiratory system.
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