Author: Carolina Corrêa Giron; Aatto Laaksonen; Fernando L. Barroso da Silva
Title: On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2 Document date: 2020_4_10
ID: 4mv6qwpc_25
Snippet: The binding affinity of this computer-designed molecule was tested. The calculated w(r) for this new fragment of mAb is given in Figure 8 . As it can be seen, CR3022' is now able to bind with an equivalent binding affinity to what was observed for the SARS-CoV-1S RBD-CR3022 system. βwmin decreased from −0.79 to −0.85 recovering the value found for the SARS-CoV-1 S RBD-CR3022 case − see Figure 6 and Table S1 . Therefore, this is a promising.....
Document: The binding affinity of this computer-designed molecule was tested. The calculated w(r) for this new fragment of mAb is given in Figure 8 . As it can be seen, CR3022' is now able to bind with an equivalent binding affinity to what was observed for the SARS-CoV-1S RBD-CR3022 system. βwmin decreased from −0.79 to −0.85 recovering the value found for the SARS-CoV-1 S RBD-CR3022 case − see Figure 6 and Table S1 . Therefore, this is a promising designed mAb candidate to be carefully and systematically examined in further experimental assays.
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