Author: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan
Title: A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors Document date: 2020_4_15
ID: 5r0u2mmo_26
Snippet: We identified transcription regulatory elements for CA5B and PIR that are active in lung tissue 190 and are located within the ACE2 gene. We also identified a transcription regulatory element 191 (located in the BMX gene, adjacent to ACE2) for the PIR and VSP13C genes. It is sterically 192 impossible for a single DNA sequence to simultaneously be transcribed and regulate another 193 gene through a physical connection. Therefore, we propose that S.....
Document: We identified transcription regulatory elements for CA5B and PIR that are active in lung tissue 190 and are located within the ACE2 gene. We also identified a transcription regulatory element 191 (located in the BMX gene, adjacent to ACE2) for the PIR and VSP13C genes. It is sterically 192 impossible for a single DNA sequence to simultaneously be transcribed and regulate another 193 gene through a physical connection. Therefore, we propose that SARS-CoV-2-induced 194 chromatin-dependent repression of ACE2 expression in lung enables the regulatory sites, 195
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