Author: Rui Xiong; Leike Zhang; Shiliang Li; Yuan Sun; Minyi Ding; Yong Wang; Yongliang Zhao; Yan Wu; Weijuan Shang; Xiaming Jiang; Jiwei Shan; Zihao Shen; Yi Tong; Liuxin Xu; Chen Yu; Yingle Liu; Gang Zou; Dimitri Lavillete; Zhenjiang Zhao; Rui Wang; Lili Zhu; Gengfu Xiao; Ke Lan; Honglin Li; Ke Xu
Title: Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2 Document date: 2020_3_12
ID: hq5um68k_48
Snippet: The 293T cells were seeded into 24-well plates at 1×10 5 respectively. Diluted compounds were given by intraperitoneal (i.p) injection once a day. The drug treatment was initiated on days 0, 3, 5, 6, 7 post-infection respectively and continued for several days. Animal weight and survival were monitored daily, and mice were euthanized until the end of the experiment or when body-weight lost more than 25%......
Document: The 293T cells were seeded into 24-well plates at 1×10 5 respectively. Diluted compounds were given by intraperitoneal (i.p) injection once a day. The drug treatment was initiated on days 0, 3, 5, 6, 7 post-infection respectively and continued for several days. Animal weight and survival were monitored daily, and mice were euthanized until the end of the experiment or when body-weight lost more than 25%.
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