Author: Rodriguesâ€Diez, Raul R.; Tejeraâ€Muñoz, Antonio; Marquezâ€Exposito, Laura; Rayegoâ€Mateos, Sandra; Sanchez, Laura Santos; Marchant, Vanessa; Santamaria, LucÃa Tejedor; Ramos, Adrian M.; Ortiz, Alberto; Egido, Jesus; Ruizâ€Ortega, Marta
Title: Statins: Could an old friend help the fight against COVIDâ€19? Cord-id: nglihgpx Document date: 2020_6_19
ID: nglihgpx
Snippet: COVIDâ€19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) has overwhelmed Healthcare Systems requiring the rapid development of treatments, at least, to reduce COVIDâ€19 severity. Drug repurposing offers a fast track. Here, we discuss the potential beneficial effects of statins in COVIDâ€19 patients based on evidence that they may target virus receptors, replication, degradation and downstream responses in infected cells, addressing both basic research
Document: COVIDâ€19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) has overwhelmed Healthcare Systems requiring the rapid development of treatments, at least, to reduce COVIDâ€19 severity. Drug repurposing offers a fast track. Here, we discuss the potential beneficial effects of statins in COVIDâ€19 patients based on evidence that they may target virus receptors, replication, degradation and downstream responses in infected cells, addressing both basic research and epidemiological information. Briefly, statins could act modulating virus entry, acting on the SARSâ€CoVâ€2 receptors, ACE2 and CD147, and/or lipid rafts engagement. Statins, by inducing autophagy activation, could regulate virus replication or degradation, exerting protective effects. The wellâ€known antiâ€inflammatory properties of statins, by blocking several molecular mechanisms, including NFâ€ÎºB and NLRP3 inflammasome, could limit the “cytokine storm†in severe COVIDâ€19 patients which is linked to fatal outcome. Finally, statin moderation of coagulation response activation may also contribute to improve COVIDâ€19 outcomes.
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