Topical Oral and Intranasal Antiviral Agents for Coronavirus Disease 2019 (COVID-19).

Hsue, Victor B; Itamura, Kyohei; Wu, Arthur W; Illing, Elisa A; Sokoloski, Kevin J; Weaver, Bree A; Anthony, Benjamin P; Hughes, Nathan; Ting, Jonathan Y; Higgins, Thomas S

With the largest viral loads in both symptomatic and asymptomatic patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) present in the oral and nasal cavities, agents that act on these two areas have the potential for large therapeutic and prophylactic benefit. A literature review was conducted to elucidate the possible agents useful in treatment of SARS-CoV-2. These agents were evaluated for their current applications, adverse reactions, their current state of study, and any future considerations in their management of coronavirus disease 2019 (COVID-2019). Our review has found that, while there are many promising agents with proven efficacy in their in-vitro efficacy against SARS-CoV-2, more clinical trials and in-vivo studies, as well as safety trials, must be conducted before these agents can be effectively implemented.