Selected article for: "adenosine diphosphate and adp adenosine diphosphate"
Author: Hopp, Ann-Katrin; Hottiger, Michael O.
Title: Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight
  • Cord-id: lkezb7fw
  • Document date: 2021_3_19
    • ID: lkezb7fw
    Snippet: Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD(+))-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60 years, comparably little is known about the physiological function of mono-ADP-ribosylation and the enzymes involved in its turnover. Promising technological advances have enabled the development of innovative tools to de
    Document: Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD(+))-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60 years, comparably little is known about the physiological function of mono-ADP-ribosylation and the enzymes involved in its turnover. Promising technological advances have enabled the development of innovative tools to detect NAD(+) and NAD(+)/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes. Here, we discuss the recent technological advances, as well as associated new biological findings and concepts.

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