Author: Yongjun Tan; Theresa Schneider; Matthew Leong; L Aravind; Dapeng Zhang
Title: Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis Mechanisms of SARS-Related Coronaviruses Document date: 2020_3_7
ID: h5ire02h_24
Snippet: The presence of multiple Ig domains with different affinities in CoVs prompted us to more generally 215 survey animal viruses for Ig domains. By using the Pfam models (39) and our own PSSMs created from 216 PSI-BLAST runs with Ig domains (12), we were able to identify about 17 distinct viral Ig domain families 217 in a wider diversity of animal viruses ( Figure 3B and Table S2 ). In addition to CoVs, such Ig domain 218 proteins can be found in ad.....
Document: The presence of multiple Ig domains with different affinities in CoVs prompted us to more generally 215 survey animal viruses for Ig domains. By using the Pfam models (39) and our own PSSMs created from 216 PSI-BLAST runs with Ig domains (12), we were able to identify about 17 distinct viral Ig domain families 217 in a wider diversity of animal viruses ( Figure 3B and Table S2 ). In addition to CoVs, such Ig domain 218 proteins can be found in adenoviruses, NCLDVs, Herpesviruses and Phenuiviruses. These viral Ig domains 219 are highly divergent; many of them are only found in certain viral groups. However, the majority have an While ORF8 is a paralog of ORF7a, its lack of the TM segment, unique insert and significantly more rapid 247 evolution suggest that it has acquired a distinct function and has been under strong positive selection 248
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