Author: Pan Shen; Qijian Zheng; Aishi Xu; Junhua Liu; Yushan Hou; Chao Gao; Chunyan Tian; Fuchu He; Dong Yang
Title: Novel non-transposable-element regulation patterns of KZFP family reveal new drivers of its rapid evolution Document date: 2020_4_16
ID: kzj28xik_3
Snippet: The zinc finger similarity between each KZFP pairs was calculated according to the 450 method described previously . Briefly, similarity between two 451 zinc finger arrays was defined as sharing the same three amino acids at the 452 DNA-contacting residues, allowing up to one replacement by a related amino acid (as 453 defined by Blosum62). To identify paralogs of human KZFPs based on zinc fingers: 1) 454 for the KZFP which containing 5 or more z.....
Document: The zinc finger similarity between each KZFP pairs was calculated according to the 450 method described previously . Briefly, similarity between two 451 zinc finger arrays was defined as sharing the same three amino acids at the 452 DNA-contacting residues, allowing up to one replacement by a related amino acid (as 453 defined by Blosum62). To identify paralogs of human KZFPs based on zinc fingers: 1) 454 for the KZFP which containing 5 or more zinc fingers, the threshold similarity score 455 of 60% and common zinc-fingers of 5 between any two zinc-finger arrays were 456 selected; for the KZFP which containing 4 or less zinc fingers, a threshold similarity 457 score of 100% between any two zinc-finger arrays was selected.
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