Author: Felix Grünberger; Robert Knüppel; Michael Jüttner; Martin Fenk; Andreas Borst; Robert Reichelt; Winfried Hausner; Jörg Soppa; Sebastien Ferreira-Cerca; Dina Grohmann
Title: Nanopore-based native RNA sequencing provides insights into prokaryotic transcription, operon structures, rRNA maturation and modifications Document date: 2019_12_19
ID: e5p4metz_24
Snippet: Illumina sequencing-based approaches that make use of a specialised library preparation design 332 to tackle a well-defined question 8 , we evaluated the potential of native RNA sequencing to analyse 333 multiple transcriptomic features simultaneously including the identification of cis-regulatory 334 elements that govern transcription, the analysis of operon structures and transcriptional 335 boundaries, rRNA processing and 16S rRNA modification.....
Document: Illumina sequencing-based approaches that make use of a specialised library preparation design 332 to tackle a well-defined question 8 , we evaluated the potential of native RNA sequencing to analyse 333 multiple transcriptomic features simultaneously including the identification of cis-regulatory 334 elements that govern transcription, the analysis of operon structures and transcriptional 335 boundaries, rRNA processing and 16S rRNA modification patterns (see Supplementary Fig. 1b Table 1 ). Due to large differences in the composition 357 of the RNAs used to train the basecaller and the sequenced reads, that contain mostly ribosomal 358
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