Author: Ingrid Arevalo-Rodriguez; Diana Buitrago-Garcia; Daniel Simancas-Racines; Paula Zambrano-Achig; Rosa del Campo; Agustin Ciapponi; Omar Sued; Laura Martinez-Garcia; Anne Rutjes; Nicola Low; Jose A Perez-Molina; Javier Zamora
Title: FALSE-NEGATIVE RESULTS OF INITIAL RT-PCR ASSAYS FOR COVID-19: A SYSTEMATIC REVIEW Document date: 2020_4_21
ID: g8h6trql_10
Snippet: The availability of accurate laboratory tools for COVID-19 is essential for case identification, contact 97 tracing, and optimization of infection control measures, as it was shown by previous epidemics 98 caused by SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) [17] [18] [19] . Due 99 to the COVID-19 pandemic causing an important burden on health systems around the globe, and 100 considering that a missing COVID 19 case mig.....
Document: The availability of accurate laboratory tools for COVID-19 is essential for case identification, contact 97 tracing, and optimization of infection control measures, as it was shown by previous epidemics 98 caused by SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) [17] [18] [19] . Due 99 to the COVID-19 pandemic causing an important burden on health systems around the globe, and 100 considering that a missing COVID 19 case might have severe consequences at several levels, we 101 aimed to estimate through a systematic review of the literature the proportion of false-negatives 102 related to the detection of SARS-CoV-2 using RT-PCR assays at the initial laboratory test. 103 104
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