Author: Villarino, Elsa; Deng, Xianding; Kemper, Carol A; Jorden, Michelle A; Bonin, Brandon; Rudman, Sarah L; Han, George S; Yu, Guixia; Wang, Candace; Federman, Scot; Bushnell, Brian; Wadford, Debra A; Lin, Wen; Tao, Ying; Paden, Clinton R; Bhatnagar, Julu; MacCannell, Tara; Tong, Suxiang; Batson, Joshua; Chiu, Charles Y
Title: Introduction, Transmission Dynamics, and Fate of Early SARS-CoV-2 Lineages in Santa Clara County, California Cord-id: qfk7vs9b Document date: 2021_4_21
ID: qfk7vs9b
Snippet: We combined viral genome sequencing with contact tracing to investigate introduction and evolution of SARS-CoV-2 lineages in Santa Clara County, California from January 27 to March 21, 2020. Of 558 persons with COVID-19, 101 genomes from 143 available clinical samples comprised 17 different lineages including SCC1 (n=41), WA1 (n=9, including the first 2 reported deaths in the United States, diagnosed post-mortem), D614G (n=4), ancestral Wuhan Hu-1 (n=21), and 13 others (n=26). Public health inte
Document: We combined viral genome sequencing with contact tracing to investigate introduction and evolution of SARS-CoV-2 lineages in Santa Clara County, California from January 27 to March 21, 2020. Of 558 persons with COVID-19, 101 genomes from 143 available clinical samples comprised 17 different lineages including SCC1 (n=41), WA1 (n=9, including the first 2 reported deaths in the United States, diagnosed post-mortem), D614G (n=4), ancestral Wuhan Hu-1 (n=21), and 13 others (n=26). Public health intervention may have curtailed the persistence of lineages that appeared transiently during February–March. By August, only D614G lineages introduced after March 21 were circulating in SCC.
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