Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_11
Snippet: Protein sequence alignment analyses indicated that the 2019-nCoV was most evolutionarily conserved with SARS-CoV (Supplementary Table S2 ). Specifically, the envelope and nucleocapsid proteins of 2019-nCoV are two evolutionarily conserved regions, with sequence identities of 96% and 89.6%, respectively, compared to SARS- Table S2 ). However, the spike protein exhibited the lowest sequence conservation (sequence identity of 77%) between 2019-nCoV .....
Document: Protein sequence alignment analyses indicated that the 2019-nCoV was most evolutionarily conserved with SARS-CoV (Supplementary Table S2 ). Specifically, the envelope and nucleocapsid proteins of 2019-nCoV are two evolutionarily conserved regions, with sequence identities of 96% and 89.6%, respectively, compared to SARS- Table S2 ). However, the spike protein exhibited the lowest sequence conservation (sequence identity of 77%) between 2019-nCoV and SARS-CoV. Meanwhile, the spike protein of 2019-nCoV only has 31.9% sequence identity compared to MERS-CoV.
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