Selected article for: "International license and viral protein"
Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus
  • Document date: 2020_2_5
    • ID: b4mdiont_9
    Snippet: HCoVs have five major protein regions for virus structure assembly and viral replications [27] , including replicase complex (ORF1ab), spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins ( Figure 2B) . The ORF1ab gene encodes the non-structural proteins (nsp) of viral RNA synthesis complex through proteolytic processing [28] . The nsp12 is a viral RNA-dependent RNA polymerase, together with cofactors nsp7 and nsp8 possessing high.....
    Document: HCoVs have five major protein regions for virus structure assembly and viral replications [27] , including replicase complex (ORF1ab), spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins ( Figure 2B) . The ORF1ab gene encodes the non-structural proteins (nsp) of viral RNA synthesis complex through proteolytic processing [28] . The nsp12 is a viral RNA-dependent RNA polymerase, together with cofactors nsp7 and nsp8 possessing high polymerase activity. From the protein threedimensional (3D) structure view of SARS-CoV nsp12, it contains a larger N-terminal extension (which binds to nsp7 and nsp8) and polymerase domain ( Figure 2C ). The . CC-BY-NC 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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