Author: Nie, Lei; Dai, Kai; Wu, Jiang; Zhou, Xia; Hu, Junjun; Zhang, Chao; Zhan, Yan; Song, Yu; Fan, Wen; Hu, Zhimin; Yang, Hongshan; Yang, Qiong; Wu, Dongde; Li, Fajiu; Li, Daoyuan; Nie, Rui
Title: Clinical characteristics and risk factors for inâ€hospital mortality of lung cancer patients with COVIDâ€19: A multicenter, retrospective, cohort study Cord-id: jvckn3hr Document date: 2020_11_3
ID: jvckn3hr
Snippet: BACKGROUND: Data on clinical, laboratory, and radiographic characteristics and risk factors for inâ€hospital mortality of lung cancer patients with COVIDâ€19 are scarce. Here, we aimed to characterize the early clinical features of lung cancer patients with COVIDâ€19 and identify risk factors associated with inâ€hospital mortality. METHODS: All consecutive lung cancer patients with laboratoryâ€confirmed COVIDâ€19 admitted to 12 hospitals in Hubei province, China, from 3 January to 6 May 20
Document: BACKGROUND: Data on clinical, laboratory, and radiographic characteristics and risk factors for inâ€hospital mortality of lung cancer patients with COVIDâ€19 are scarce. Here, we aimed to characterize the early clinical features of lung cancer patients with COVIDâ€19 and identify risk factors associated with inâ€hospital mortality. METHODS: All consecutive lung cancer patients with laboratoryâ€confirmed COVIDâ€19 admitted to 12 hospitals in Hubei province, China, from 3 January to 6 May 2020 were included in the study. Patients without definite clinical outcomes during the period were excluded. Data on initial clinical, laboratory and radiographic findings were compared between survivors and nonsurvivors. Univariable and multivariable logistic regression analyses were used to explore the risk factors associated with inâ€hospital mortality. RESULTS: Of the 45 lung cancer patients (median [interquartile range] age, 66 [58–74] years; 68.9% males) included, 34 (75.6%) discharged and 11 (24.4%) died. Fever (73.3%) and cough (53.3%) were the dominant initial symptoms, and respiratory symptoms were common. Lung cancer patients also presented atypical appearances of COVIDâ€19. In the multivariable analysis, prolonged prolongation prothrombin time (PT) (OR = 2.1, 95% CI: 1.00–4.41, P = 0.0497) and elevated high sensitivity cardiac troponin I (hsâ€TNI) (OR = 7.65, 95% CI: 1.24–47.39, P = 0.0287) were associated with an increased risk of inâ€hospital mortality. CONCLUSIONS: Lung cancer patients with COVIDâ€19 have high inâ€hospital mortality. Prolonged PT and elevated hsâ€TNI are independent risk factors for inâ€hospital mortality of lung cancer patients with COVIDâ€19. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: Lung cancer patients with COVIDâ€19 have atypical early symptoms and imaging features. The prolonged prothrombin time and elevated high sensitivity cardiac troponin I are independent risk factors for inâ€hospital mortality of lung cancer patients with COVIDâ€19. WHAT THIS STUDY ADDS: This study characterizes the early clinical features of lung cancer patients with COVIDâ€19 in China, and identifies the risk factors associated with inâ€hospital mortality of lung cancer patients with COVIDâ€19.
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