Selected article for: "CRISPR screen and host protein"
Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy
  • Document date: 2020_3_30
    • ID: 0l33i6s4_22
    Snippet: The two pathways identified by both CRISPR screen and siRNA screen, endocytosis and 29 protein secretion, have previously been implicated in human host response to a number of viral 30 pathogens 13, 21, 23 To validate the role of these pathways in the bat response to viral infection, we 31 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . .....
    Document: The two pathways identified by both CRISPR screen and siRNA screen, endocytosis and 29 protein secretion, have previously been implicated in human host response to a number of viral 30 pathogens 13, 21, 23 To validate the role of these pathways in the bat response to viral infection, we 31 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020. 03.29.014209 doi: bioRxiv preprint established PaKi stable cell lines expressing shRNAs targeting several hits from the two screens. 1

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