Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy Document date: 2020_3_30
ID: 0l33i6s4_3
Snippet: Additionally, we revealed a general dependence of the C-1-tetrahydrofolate synthase gene, 11 MTHFD1, for viral replication in bat cells as well as in human cells. MTHFD1 inhibitor carolacton 12 potently blocked replication of several RNA viruses including SARS-CoV-2. Our studies provide 13 a resource for systematic inquiry into the genetic underpinnings of bat biology and a potential 14 target for developing broad spectrum antiviral therapy. viru.....
Document: Additionally, we revealed a general dependence of the C-1-tetrahydrofolate synthase gene, 11 MTHFD1, for viral replication in bat cells as well as in human cells. MTHFD1 inhibitor carolacton 12 potently blocked replication of several RNA viruses including SARS-CoV-2. Our studies provide 13 a resource for systematic inquiry into the genetic underpinnings of bat biology and a potential 14 target for developing broad spectrum antiviral therapy. viruses, causing the epidemics of the Ebola 1 , SARS 2 , Henipavirus 3 , MERS 4 and 6 . 20
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