Author: Jingyue Ju; Xiaoxu Li; Shiv Kumar; Steffen Jockusch; Minchen Chien; Chuanjuan Tao; Irina Morozova; Sergey Kalachikov; Robert N. Kirchdoerfer; James J. Russo
Title: Nucleotide Analogues as Inhibitors of SARS-CoV Polymerase Document date: 2020_3_14
ID: hj675z1b_1
Snippet: formed, which is responsible for making more copies of the RNA genome via a negative-sense RNA intermediate, as well as the structural and other proteins encoded by the viral genome. The viral RNA is packaged into viral coats in the endoplasmic reticulum-Golgi intermediate complex, after which exocytosis results in release of viral particles for subsequent infectious cycles. Potential inhibitors have been designed to target nearly every stage of .....
Document: formed, which is responsible for making more copies of the RNA genome via a negative-sense RNA intermediate, as well as the structural and other proteins encoded by the viral genome. The viral RNA is packaged into viral coats in the endoplasmic reticulum-Golgi intermediate complex, after which exocytosis results in release of viral particles for subsequent infectious cycles. Potential inhibitors have been designed to target nearly every stage of this process. 3 However, despite decades of research, no effective drug is currently approved to treat serious coronavirus infections such as SARS, MERS, and COVID-19.
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