Selected article for: "admission frequent and logistic regression"
Author: Bavaro, D. F.; Diella, L.; Fabrizio, C.; Sulpasso, R.; Bottalico, I. F.; Calamo, A.; Santoro, C. R.; Brindicci, G.; Bruno, G.; Mastroianni, A.; Buccoliero, G. B.; Carbonara, S.; Lo Caputo, S.; Santantonio, T.; Monno, L.; Angarano, G.; Saracino, A.
Title: Peculiar clinical presentation of COVID- 19 and predictors of mortality in the elderly: a Multicentre Retrospective Cohort Study
  • Cord-id: lvewxgaz
  • Document date: 2021_3_17
    • ID: lvewxgaz
    Snippet: Background The spectrum of clinical manifestations of CoronaVirus Disease-19 (COVID-19) is not yet completely known. In elderly, mortality and extra-pulmonary involvement appear to be more frequent than expected. Methods A multicentric-retrospective-case-series of patients hospitalized between March 1st and June 15th, 2020 with confirmed COVID-19 by RT-PCR testing on throat/nasopharyngeal swabs and age ≥65 years was analysed. Based on the “Clinical Frailty Scale” (CFS), patients were class
    Document: Background The spectrum of clinical manifestations of CoronaVirus Disease-19 (COVID-19) is not yet completely known. In elderly, mortality and extra-pulmonary involvement appear to be more frequent than expected. Methods A multicentric-retrospective-case-series of patients hospitalized between March 1st and June 15th, 2020 with confirmed COVID-19 by RT-PCR testing on throat/nasopharyngeal swabs and age ≥65 years was analysed. Based on the “Clinical Frailty Scale” (CFS), patients were classified into three groups according to the resulting score: 1-3 (group A), 4-6 (group B), 7-9 (group C). Results Overall, 206 patients were included. Crude mortality was 27%. According to CFS, on admission, 60 patients (29%) were assigned to group A, 60 (29%) to group B, and 86 (42%) to group C. The following features were significantly more frequent among group C patients in comparison with groups B and A: mental confusion (65% vs 33% vs 7%, respectively, p < .001), kidney failure (39% vs 22% vs 20%, p = .019), dehydration syndrome (55% vs 27% vs 13%, p < .001), electrolyte imbalance (54% vs 32% vs 25%, p = .001), and diabetic decompensation (22% vs 12% vs 7%, p = .026). By multivariable logistic regression model, male sex (aOR = 2.87, 95%CI = 1.15–7.18), CFS between 7 and 9 (aOR = 9.97, 95%CI = 1.82–52.99), dehydration at admission (aOR = 4.27, 95%CI = 1.72–10.57), and non-invasive/invasive ventilation (aOR = 4.88, 95%CI = 1.94–12-26) were independent predictors of death. Conclusions Elderly with a high CFS showed frequent extrapulmonary signsat admission, even in absence of lung involvement. These findings, along with a high CFS, predicted a significant risk of mortality.

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