Author: Santeusanio, Andrew D.; Menon, Madhav C.; Liu, Caroline; Bhansali, Arjun; Patel, Niralee; Mahir, Fahima; Rana, Meenakshi; Tedla, Fasika; Mahamid, Ahmad; Fenig, Yaniv; Zendel, Alexey; Delaney, Veronica; De Boccardo, Graciela; Farouk, Samira S.; Sehgal, Vinita; Khaim, Rafael; Jacobs, Samantha E.; Dunn, Dallas; Sullivan, Timothy; Taimur, Sarah; Baneman, Emily; Florman, Sander; Shapiro, Ron
Title: Influence of patient characteristics and immunosuppressant management on mortality in kidney transplant recipients hospitalized with coronavirus disease 2019 (COVIDâ€19) Cord-id: ssuv806d Document date: 2021_1_21
ID: ssuv806d
Snippet: The influence of patient characteristics and immunosuppression management on COVIDâ€19 outcomes in kidney transplant recipients (KTRs) remains uncertain. We performed a singleâ€center, retrospective review of all adult KTRs admitted to the hospital with confirmed COVIDâ€19 between 03/15/2020 and 05/15/2020. Patients were followed from the date of admission up to 1 month following hospital discharge or study conclusion (06/15/2020). Baseline characteristics, laboratory parameters, and immunosu
Document: The influence of patient characteristics and immunosuppression management on COVIDâ€19 outcomes in kidney transplant recipients (KTRs) remains uncertain. We performed a singleâ€center, retrospective review of all adult KTRs admitted to the hospital with confirmed COVIDâ€19 between 03/15/2020 and 05/15/2020. Patients were followed from the date of admission up to 1 month following hospital discharge or study conclusion (06/15/2020). Baseline characteristics, laboratory parameters, and immunosuppression were compared between survivors and patients who died to identify predictors of mortality. 38 KTRs with a mean baseline eGFR of 52.5 ml/min/1.73 m(2) were hospitalized during the review period. Maintenance immunosuppression included tacrolimus (84.2%), mycophenolate (89.5%), and corticosteroids (81.6%) in the majority of patients. Eleven patients (28.9%) died during the hospitalization. Older age (OR = 2.05; 1.04â€4.04), peak Dâ€dimer (OR = 1.20; 1.04â€1.39), and peak white blood cell count (OR = 1.11; 1.02â€1.21) were all associated with mortality among KTRs hospitalized for COVIDâ€19. Increased mortality was also observed among KTRs with concomitant HIV infection (87.5% vs. 36.1%; p < .01). Conversely, immunosuppression intensity and degree of reduction following COVIDâ€19 diagnosis were not associated with either survival or acute allograft rejection. Our findings potentially support a strategy of individualization of immunosuppression targets based on patientâ€specific risk factors, rather than universal immunosuppression reduction for KTRs at risk from COVIDâ€19.
Search related documents:
Co phrase search for related documents- absolute alc lymphocyte count and lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- active malignancy and acute kidney injury: 1, 2
- active malignancy and acute kidney injury incidence: 1
- active malignancy and acute rejection: 1
- active malignancy and acute respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7
- active malignancy and logistic regression: 1, 2, 3, 4
- acute kidney injury and additional study: 1, 2, 3
- acute kidney injury and admission follow: 1, 2, 3, 4, 5
- acute kidney injury and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute kidney injury and lymphocyte count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
- acute kidney injury incidence and additional study: 1
- acute kidney injury incidence and admission follow: 1
- acute kidney injury incidence and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute kidney injury incidence and lymphocyte count: 1, 2, 3
- acute rejection and logistic regression: 1, 2, 3, 4, 5, 6
- acute rejection and lymphocyte count: 1
- acute respiratory distress syndrome and additional study: 1, 2, 3, 4, 5, 6, 7
- acute respiratory distress syndrome and admission follow: 1, 2, 3
- acute respiratory distress syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
Co phrase search for related documents, hyperlinks ordered by date