Author: Darko Bosnakovski; Erik A. Toso; Olivia O. Recht; Anja Cucak; Abhinav K Jain; Michelle C. Barton; Michael Kyba
Title: p53 is not necessary for DUX4 pathology Document date: 2017_3_19
ID: jopeo9gs_22
Snippet: The p53 mutant allele used in these studies was obtained from Jackson Labs (strain 008651) and carries a floxed stop codon upstream of a dominant negative (R270H) p53 mutant. In the absence of cre, no functional p53 is produced, thus as used in the current study, it is a null allele. Mice homozygous for this allele developed papillomas and most eventually succumbed to thymic lymphomas, as predicted for a p53 null......
Document: The p53 mutant allele used in these studies was obtained from Jackson Labs (strain 008651) and carries a floxed stop codon upstream of a dominant negative (R270H) p53 mutant. In the absence of cre, no functional p53 is produced, thus as used in the current study, it is a null allele. Mice homozygous for this allele developed papillomas and most eventually succumbed to thymic lymphomas, as predicted for a p53 null.
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