Author: Ainge, James A.; Chisari, Mariangela Cohen Akiva Mennerick Steven J.; Topolnik, Lisa Meier Jochen C.
Title: Editorial: Spring Hippocampal Research Conference and Beyond Cord-id: t4mwlhv0 Document date: 2021_1_1
ID: t4mwlhv0
Snippet: In spite of increased food intake, the transgenic mice were significantly leaner than their wildtype littermates. Furthermore, reduction of TrkB in 5-HT neurons increased proliferation, but not long-term survival, of hippocampal cells that was consistent with increase in immature neuronal markers such as doublecortin and calretinin in the transgenic animals. Bartsch and Behr used N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 to model first-episode psychosis in rats and studied long-ter
Document: In spite of increased food intake, the transgenic mice were significantly leaner than their wildtype littermates. Furthermore, reduction of TrkB in 5-HT neurons increased proliferation, but not long-term survival, of hippocampal cells that was consistent with increase in immature neuronal markers such as doublecortin and calretinin in the transgenic animals. Bartsch and Behr used N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 to model first-episode psychosis in rats and studied long-term potentiation (LTP) in subicular regular-firing cells in acute hippocampal slices. The authors provide evidence for a non-canonical postsynaptic NMDAR-independent LTP in ventral subicular but not in CA1 regular-firing pyramidal cells, which was dependent on D1/D5 dopamine receptor activation, postsynaptic Ca2+ signaling and activation of protein kinase A. This aberrant form of LTP in ventral subicular regular-firing neurons was suggested to interfere with physiological hippocampal output processing and to contribute to hippocampal dysfunction in psychotic events.
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