Author: Caruso, Arnaldo; Caccuri, Francesca; Bugatti, Antonella; Zani, Alberto; Vanoni, Marco; Bonfanti, Paolo; Cazzaniga, Marina E.; Perno, Carlo F.; Messa, Cristina; Alberghina, Lilia
Title: Methotrexate inhibits SARSâ€CoVâ€2 virus replication “in vitro†Cord-id: tpagtsyu Document date: 2020_9_28
ID: tpagtsyu
Snippet: In early 2020 the new respiratory syndrome COVIDâ€19 (caused by the zoonotic SARSâ€CoVâ€2 virus) spread like a pandemic, starting from Wuhan, China, causing severe economic depression. Despite some advances in drug treatments of medical complications in the later stages of the disease, the pandemic's death toll is tragic, as no vaccine or specific antiviral treatment is currently available. By using a systems approach, we identify the hostâ€encoded pathway, which provides ribonucleotides to
Document: In early 2020 the new respiratory syndrome COVIDâ€19 (caused by the zoonotic SARSâ€CoVâ€2 virus) spread like a pandemic, starting from Wuhan, China, causing severe economic depression. Despite some advances in drug treatments of medical complications in the later stages of the disease, the pandemic's death toll is tragic, as no vaccine or specific antiviral treatment is currently available. By using a systems approach, we identify the hostâ€encoded pathway, which provides ribonucleotides to viral RNA synthesis, as a possible target. We show that methotrexate, an FDAâ€approved inhibitor of purine biosynthesis, potently inhibits viral RNA replication, viral protein synthesis, and virus release. The effective antiviral methotrexate concentrations are similar to those used for established human therapies using the same drug. Methotrexate should be most effective in patients at the earliest appearance of symptoms to effectively prevent viral replication, diffusion of the infection, and possibly fatal complications.
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