Author: Kenichiro Sato; Tatsuo Mano; Atsushi Iwata; Tatsushi Toda
Title: Neuropsychiatric adverse events of chloroquine: A real-world pharmacovigilance study using the FAERS database Document date: 2020_4_14
ID: buzj06i6_12
Snippet: In the FAERS database, the AEs are mainly identified by their Preferred Terms (PTs), as determined by the Medical Dictionary for Regulatory Activities (MedDRA). To search for cases that were associated with chloroquine (including hydroxychloroquine) or mefloquine treatment and presented with any of the AEs of interest, we used the following neurological or psychiatric AE terms, as summarized in Supplemental Table 1 We included mefloquine as one o.....
Document: In the FAERS database, the AEs are mainly identified by their Preferred Terms (PTs), as determined by the Medical Dictionary for Regulatory Activities (MedDRA). To search for cases that were associated with chloroquine (including hydroxychloroquine) or mefloquine treatment and presented with any of the AEs of interest, we used the following neurological or psychiatric AE terms, as summarized in Supplemental Table 1 We included mefloquine as one of our drugs of interest because it is an antimalarial drug that is known to cause neuropsychiatric AEs [12] . We classified each case report based on the following binomial factors: 'with' or 'without' exposure to the drugs of interest, and 'with' or 'without' the development of each of the AEs of interest, irrespective of the timing of drug administration or the time of AE development.
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