Author: Arlin Stoltzfus; Ryan W. Norris
Title: On the causes of evolutionary transition:transversion bias Document date: 2015_9_28
ID: 4xocqn6o_39
Snippet: However, the same studies typically do not show significant conservativeness of transitions. Overall, the chance of a transition mutation being more fit than a . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/027722 doi: bioRxiv preprint transversion is 53 % (95 % CI, 50 % to 56 %). This effect size is not large compa.....
Document: However, the same studies typically do not show significant conservativeness of transitions. Overall, the chance of a transition mutation being more fit than a . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/027722 doi: bioRxiv preprint transversion is 53 % (95 % CI, 50 % to 56 %). This effect size is not large compared to that of most biochemical predictors, and is not large enough to explain the several-fold bias toward transition replacements observed in evolutionary studies.
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