Selected article for: "ACEi drug and lung expression"
Author: Dipender Gill; Marios Arvanitis; Paul Carter; Ana I Hernandez Cordero; Brian Jo; Ville Karhunen; Susanna C Larsson; Xuan Li; Sam M Lockhart; Amy M Mason; Evanthia Pashos; Ashis Saha; Vanessa Tan; Verena Zuber; Yohan Bosse; Sarah Fahle; Ke Hao; Tao Jiang; Philippe Joubert; Alan C Lunt; Willem hendrik Ouwehand; David J Roberts; Wim Timens; Maarten van den Berge; Nicholas A Watkins; Alexis Battle; Adam S Butterworth; John Danesh; Barbara E Engelhard; James E Peters; Don Sin; Stephen Burgess
Title: ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study
  • Document date: 2020_4_14
    • ID: 1kkpx108_40
    Snippet: In the current COVID-19 pandemic, there is an urgent need to elucidate mechanisms underlying risk and severity of COVID-19, with a view to informing preventative and therapeutic strategies. In this study, we used human genetic variants that proxy ACEi drug effects and cardiometabolic risk factors to provide insight into how these exposures affect lung ACE2 and TMPRSS2 expression, and circulating ACE2 levels......
    Document: In the current COVID-19 pandemic, there is an urgent need to elucidate mechanisms underlying risk and severity of COVID-19, with a view to informing preventative and therapeutic strategies. In this study, we used human genetic variants that proxy ACEi drug effects and cardiometabolic risk factors to provide insight into how these exposures affect lung ACE2 and TMPRSS2 expression, and circulating ACE2 levels.

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