Author: Ali Gibran; Runzhen Zhao; Mo Zhang; Krishan G. Jain; Jianjun Chang; Satoshi Komatsu; Xiaohui Fang; Beiyun Zhou; Jiurong Liang; Dianhua Jiang; Mistuo Ikebe; Michael A Matthay; Hong-Long Ji
Title: Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair Document date: 2020_3_25
ID: 4h930ksd_19
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.24.006270 doi: bioRxiv preprint of injured muscle is improved by knocking out the Serpine1 gene142. The Plau gene regulates the proliferation of various cells, including renal epithelial cells43 , 44, umbilical vein endothelial cells45, vascular endothelial cells46, and keratinocytes47 , 48. Contrary to this, Serpine1 is a negative regula.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.24.006270 doi: bioRxiv preprint of injured muscle is improved by knocking out the Serpine1 gene142. The Plau gene regulates the proliferation of various cells, including renal epithelial cells43 , 44, umbilical vein endothelial cells45, vascular endothelial cells46, and keratinocytes47 , 48. Contrary to this, Serpine1 is a negative regulator of cell proliferation through the phosphatidylinositol3-kinase/Akt pathway in endothelial cells49 , 50. Our study uncovers a new signaling pathway of the fibrinolytic niche in the AT2 cell-mediated re-alveolarization. The uPA/A6/CD44 /ENaC cascade is involved in the regulation of self-renewal and differentiation of mouse and human AT2 cells, particularly the CD44 + subpopulation. This conclusion was further substantiated in Serpine1 Tg mice that have a disrupted fibrinolytic niche similar to the Plau -/mice, and both mouse lines are reasonable pre-clinical models of ARDS.
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