Author: Dipender Gill; Marios Arvanitis; Paul Carter; Ana I Hernandez Cordero; Brian Jo; Ville Karhunen; Susanna C Larsson; Xuan Li; Sam M Lockhart; Amy M Mason; Evanthia Pashos; Ashis Saha; Vanessa Tan; Verena Zuber; Yohan Bosse; Sarah Fahle; Ke Hao; Tao Jiang; Philippe Joubert; Alan C Lunt; Willem hendrik Ouwehand; David J Roberts; Wim Timens; Maarten van den Berge; Nicholas A Watkins; Alexis Battle; Adam S Butterworth; John Danesh; Barbara E Engelhard; James E Peters; Don Sin; Stephen Burgess
Title: ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study Document date: 2020_4_14
ID: 1kkpx108_47
Snippet: (which was not peer-reviewed) The copyright holder for this preprint . Figure 1 . Genetic associations with ACE2 and TMPRSS2 gene expression in the lung (GTEx and Lung consortium) and circulating ACE2 protein levels in the plasma (INTERVAL): a) per one standard deviation increased ACE concentration conferred through variants at the ACE gene, and b) per blood pressure-lowering allele for the rs4291 variant in the ACE gene (bottom panel). The two s.....
Document: (which was not peer-reviewed) The copyright holder for this preprint . Figure 1 . Genetic associations with ACE2 and TMPRSS2 gene expression in the lung (GTEx and Lung consortium) and circulating ACE2 protein levels in the plasma (INTERVAL): a) per one standard deviation increased ACE concentration conferred through variants at the ACE gene, and b) per blood pressure-lowering allele for the rs4291 variant in the ACE gene (bottom panel). The two sets of results for TMPRSS2 expression in the Lung eQTL consortium refer to two separate probe sets for estimating gene expression. a.
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