Author: Rosanna Asselta; Elvezia Maria Paraboschi; Alberto Mantovani; Stefano Duga
Title: ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy Document date: 2020_4_2
ID: hrottr01_34
Snippet: In conclusion, we have explored possible genetic components impacting on the sexbiased severity of COVID-19, focusing on effects mediated by ACE2 and TMPRSS2 genes in the Italian population. From available data, it seems unlikely that sexdifferences in ACE2 levels can explain sex differences in disease severity. However, it remains to be evaluated if changes in ACE2 levels in the lung correlate with susceptibility and severity of SARS-CoV-2 infec.....
Document: In conclusion, we have explored possible genetic components impacting on the sexbiased severity of COVID-19, focusing on effects mediated by ACE2 and TMPRSS2 genes in the Italian population. From available data, it seems unlikely that sexdifferences in ACE2 levels can explain sex differences in disease severity. However, it remains to be evaluated if changes in ACE2 levels in the lung correlate with susceptibility and severity of SARS-CoV-2 infection. Experimental data from patients . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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