Author: Bruna GG Pinto; Antonio ER Oliveira; Youvika Singh; Leandro Jimenez; Andre NA Goncalves; Rodrigo LT Ogava; Rachel Creighton; Jean PS Peron; Helder I Nakaya
Title: ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19 Document date: 2020_3_27
ID: 2un9aggj_11
Snippet: (COPD), "Severe Acute Respiratory Syndrome" (SARS), "H1N1 Influenza", "Tuberculosis" and "Smoking". Author-normalized expression values and metadata from these datasets were downloaded using the GEOquery package [19] . We performed differential expression analyses between patients with a disease and the control individuals (see Table S1 ) using the limma package [20] . The gene symbol for each probe was obtained from the annotation file [21] . Pr.....
Document: (COPD), "Severe Acute Respiratory Syndrome" (SARS), "H1N1 Influenza", "Tuberculosis" and "Smoking". Author-normalized expression values and metadata from these datasets were downloaded using the GEOquery package [19] . We performed differential expression analyses between patients with a disease and the control individuals (see Table S1 ) using the limma package [20] . The gene symbol for each probe was obtained from the annotation file [21] . Probes that matched the same gene symbol were collapsed by taking the one with the lowest p-value. Meta-analysis was performed with the MetaVolcanoR package [22] by combining the p-values using Fisher's method.
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