Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy Document date: 2020_3_30
ID: 0l33i6s4_7
Snippet: We extensively characterized a common hit from the two screens, MTHFD1, and identified it as a 25 critical factor for viral replication in both bats and humans. We further demonstrate that MTHFD1 26 is a potential target for developing broad-spectrum antiviral drugs. MTHFD1 inhibitor carolacton 27 demonstrated broad antiviral activities against Zika virus, mumps virus, and importantly, SARS-28.....
Document: We extensively characterized a common hit from the two screens, MTHFD1, and identified it as a 25 critical factor for viral replication in both bats and humans. We further demonstrate that MTHFD1 26 is a potential target for developing broad-spectrum antiviral drugs. MTHFD1 inhibitor carolacton 27 demonstrated broad antiviral activities against Zika virus, mumps virus, and importantly, SARS-28
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