Author: Fabiana Renzi; Dario Ghersi
Title: ACE2 fragment as a decoy for novel SARS-Cov-2 virus Document date: 2020_4_10
ID: 77ku0164_3
Snippet: In addition, we compared the complex of another coronavirus, Cov-NL63 (pdb:3KBH), which targets the ACE2 receptor as well. The structure of Cov-NL63 shows limited structural similarity in binding to ACE2 as compared to other SARS viruses (Fig.1D ). Cov-NL63 appears to bind to a narrower area of ACE2, centered around Lys353, which interacts with the conserved viral Tyr498......
Document: In addition, we compared the complex of another coronavirus, Cov-NL63 (pdb:3KBH), which targets the ACE2 receptor as well. The structure of Cov-NL63 shows limited structural similarity in binding to ACE2 as compared to other SARS viruses (Fig.1D ). Cov-NL63 appears to bind to a narrower area of ACE2, centered around Lys353, which interacts with the conserved viral Tyr498.
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