Author: Yuri I. Wolf; Darius Kazlauskas; Jaime Iranzo; Adriana LucÍa-Sanz; Jens H. Kuhn; Mart Krupovic; Valerian V. Dolja; Eugene V. Koonin
Title: Origins and Evolution of the Global RNA Virome Document date: 2018_10_24
ID: 8z78shbf_19
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/451740 doi: bioRxiv preprint Instead, Branches 4 and 5 are separate and positioned deep in the tree, right above the split 265 between Branch 1 and the rest of the RdRps. Given the poor resolution of the RAxML tree and a 266 strong biological argument, namely, the absence of identified -RNA viruses in prokaryotes or 267 protists (w.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/451740 doi: bioRxiv preprint Instead, Branches 4 and 5 are separate and positioned deep in the tree, right above the split 265 between Branch 1 and the rest of the RdRps. Given the poor resolution of the RAxML tree and a 266 strong biological argument, namely, the absence of identified -RNA viruses in prokaryotes or 267 protists (with the exception of the "leishbuviruses" infecting kinetoplastids (49, 50); see also 268 discussion below), we believe that the tree topology in Figure 1 carries more credence than that 269 shown in Data set S3B. Nevertheless, these discrepancies emphasize that utmost caution is due 270 when biological interpretation of deep branching in trees of highly divergent proteins is 271 attempted. 272 273 All rights reserved. No reuse allowed without permission.
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