Author: Perrella, Alessandro; Brita, Mario; Coletta, Francesco; Cotena, Simona; De Marco, GiamPaola; Longobardi, Adele; Sala, Crescenzo; Sannino, Dania; Tomasello, Antonio; Perrella, Marco; Russo, Giuseppe; Tarsitano, Marina; Chetta, Massimo; Della Monica, Matteo; Orlando, Valentina; Coscioni, Enrico; Villani, Romolo
Title: SARS-CoV-2 in Urine May Predict a Severe Evolution of COVID-19 Cord-id: mf6f0wh3 Document date: 2021_9_8
ID: mf6f0wh3
Snippet: We hypothesized that the spread of SARS-CoV-2 in urine during a severe COVID-19 infection may be the expression of the worsening disease evolution. Therefore, the aim of this study was to verify if the COVID-19 disease severity is related to the viral presence in urine samples. We evaluated the clinical evolution in acute COVID-19 patients admitted in the sub-intensive care and intensive care units between 28 of December 2020 and 15th of February 2021 and being positive for SARS-CoV-2 RNA in the
Document: We hypothesized that the spread of SARS-CoV-2 in urine during a severe COVID-19 infection may be the expression of the worsening disease evolution. Therefore, the aim of this study was to verify if the COVID-19 disease severity is related to the viral presence in urine samples. We evaluated the clinical evolution in acute COVID-19 patients admitted in the sub-intensive care and intensive care units between 28 of December 2020 and 15th of February 2021 and being positive for SARS-CoV-2 RNA in the respiratory tract, including repeated endotracheal aspirates (ETA), sputum, nasopharyngeal swabs (NPS) and urine. We found that those subjects with SARS-COV-2 in the urine at admittance (8 out of 60 eligible patients) had a more severe disease than those with negative SARS-CoV-2 in urine. Further, they showed an increase in fibrinogen and (C-reactive Protein) CRP serum levels, requiring mechanic ventilation. Of those with positive SARS-CoV-2 in the urine, 50% died. According to our preliminary results, it seems that the presence of SARS-CoV-2 in the urine characterizes patients with a more severe disease and is also related to a higher death rate.
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