Author: Lau, Andy T.Y.; Chiu, Jenâ€Fu
Title: Biomarkers of lungâ€related diseases: Current knowledge by proteomic approaches Cord-id: y0s2winq Document date: 2009_8_13
ID: y0s2winq
Snippet: The lung epithelial surface is one of the vital barriers or sensors in the body responding to the external atmosphere and thereby always subjecting to direct toxicological exposure, stress, stimulus, or infection. Due to its relatively higher sensitivity in response to toxicants, the use of lung epithelial cell culture and lung tissue from animal models or patients has facilitated our learning to lung physiopathology and toxicopharmacology. The recent advancement of proteomics has made it possib
Document: The lung epithelial surface is one of the vital barriers or sensors in the body responding to the external atmosphere and thereby always subjecting to direct toxicological exposure, stress, stimulus, or infection. Due to its relatively higher sensitivity in response to toxicants, the use of lung epithelial cell culture and lung tissue from animal models or patients has facilitated our learning to lung physiopathology and toxicopharmacology. The recent advancement of proteomics has made it possible to investigate the cellular response at a global level. In this review, the potential applications of proteomic approach in studying lungâ€related diseases and biomarker discovery will be discussed. J. Cell. Physiol. 221: 535–543, 2009. © 2009 Wileyâ€Liss, Inc.
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