Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways Document date: 2019_5_24
ID: cbit5xci_28
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/647305 doi: bioRxiv preprint but SEM images suggest that this is due to aggregation, not the formation of larger nanoparticles (Supplementary Fig. 2B -C). As with the bPEI nanoparticles, IAA modification did not affect the zeta potential of the chitosan nanoparticles; both formulations had a slightly positive zeta potential (~+15 m.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/647305 doi: bioRxiv preprint but SEM images suggest that this is due to aggregation, not the formation of larger nanoparticles (Supplementary Fig. 2B -C). As with the bPEI nanoparticles, IAA modification did not affect the zeta potential of the chitosan nanoparticles; both formulations had a slightly positive zeta potential (~+15 mV) at pH 7.4.
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